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Spectral Instruments Imaging manufactures instruments for pre-clinical optical (bioluminescent, fluorescent) and X-ray imaging. The company  was founded by the coming together of pre-clinical optical imaging pioneers (Xenogen), Bo Nelson and Mike Cable, and recognized industry leaders in CCD camera technology Keith Copeland and Gary Sims.

"Engineered with superior optics and industry leading technology, Spectral Instruments Imaging provides unrivaled sensitivity for bioluminescence, fluorescence and X-ray in vivo imaging. Intelligently designed around the needs of animal scientists, all Spectral Instrument Imaging systems include a robust build, patented LED illumination source, custom filter options, -90°C cooled camera, and absolute calibration. Lago and Ami systems enable high throughput imaging and field upgradable X-ray."